Lake Manych-Gudilo is a large saltwater reservoir lake in Kalmykia, Russia. Part of the lake lies also in Rostov Oblast and Stavropol Krai. It has an area of about 344 km² and average depth of only about 0.6 m.
Lake Manych-Gudilo is the source of the West Manych River, which flows north-west, through a number of reservoirs, falling into the lower Don a short distance upstream from Rostov-on-Don and the Don's fall into the Sea of Azov.